Both test methods have drawbacks in clinical application. In addition, serum IgG/M tests have been mainly reported using enzyme immunoassay (ELISA) or rapid diagnostic kits. To compensate for these limitations, a number of SARS-CoV-2 antibody tests have been developed, but these tests have not yet been sufficiently evaluated and have not yet been applied in actual clinical practice. In addition, no information on the patient’s immunity to SARS-CoV2 infection is currently available. However, molecular diagnostic tests demonstrate a high sensitivity in the early stages of the infection, but the detection rate decreases with time. Ĭurrently, laboratory tests using molecular diagnostic methods are being conducted for the early diagnosis and isolation of infected persons. In addition, severe infections in high-risk patients are associated with a mortality rate of 2.7% in men and 1.8% in women. People infected with SARS-CoV-2 mainly show respiratory symptoms and fever and are associated with pulmonary fibrosis and systemic inflammatory diseases in children. According to the World Health Organization (WHO) dashboard, as of December 24, 2020, 76,858,506 infections and 1,711,498 deaths have been reported worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is spreading rapidly worldwide, with high mortality and infection rates. Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant databases described in this study has been deposited on the Harvard Dataverse ( ).įunding: This work was supported by the National Research Foundation of Korea (NRF) grant, funded by the Korean government (Ministry of Science, ICT & Future Planning). Received: MaAccepted: JPublished: June 29, 2021Ĭopyright: © 2021 Lee et al. PLoS ONE 16(6):Įditor: Etsuro Ito, Waseda University: Waseda Daigaku, JAPAN Citation: Lee N, Jeong S, Park M-J, Song W (2021) Comparison of three serological chemiluminescence immunoassays for SARS-CoV-2, and clinical significance of antibody index with disease severity.
0 Comments
Leave a Reply. |